Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR etc. |
| Sample | CRC tissues, cell lines (HCT-116 (p53t/t), HCT-116(p53-/-) etc.) |
| Expression Pattern | down-regulated |
| Function Description | We discovered that the expression level of lincRNA-p21 was increased by elevated wild-type p53 induced by nutlin-3 in HCT-116 colon cancer cells. The expression level of lincRNA-p21 was significantly lower in CRC tumor tissue when compared with the paired normal tissue from the same patient. |
| Pubmed ID | 24012455 |
| Year | 2013 |
| Title | Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer. |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |