Basic Information
| LncRNA/CircRNA Name | LINC-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 |
| Ensemble | ENSG00000258609 |
| Refseq | NR_048536 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Flow cytometry assay, FISH etc. |
| Sample | endometrial carcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | We began by assessing the expression of linc-RoR in ECSC growing under tumorsphere conditions and differentiated conditions (removal of bFGF). In qRT-PCR analyses, a marked reduction of linc-RoR and core TFs was observed in all differentiated tumorspheres. This finding suggested that linc-RoR expression was positively correlated with levels of undifferentiated tumorspheres. The effects of miR-145 could be eliminated after increasing the expression of linc-RoR in ETs or mutated targeted sequences in linc-RoR. |
| Pubmed ID | 24589415 |
| Year | 2014 |
| Title | Linc-RNA-RoR acts as a sponge against mediation of the differentiation of endometrial cancer stem cells by microRNA-145. |
External Links
| Links for LINC-ROR | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |