Basic Information
| LncRNA/CircRNA Name | LINC-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 |
| Ensemble | ENSG00000258609 |
| Refseq | NR_048536 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, in vitro knockdown |
| Sample | cell line(TPC1), FFPE tissue |
| Expression Pattern | up-regulated |
| Function Description | ROR was shown to exert regulatory effect in proliferation, invasion, and stemness of gastricc arcinoma stem cells and in breast cancer,pancreatic cancer, hepatocellular cancer, endometrial cancer, and naso- pharyngeal carcinomas.ROR lncRNA had a negative regulatory on miR-145.SiRNA experiments with ROR also led to increased expression of miR-145, supporting the role of ROR as an endogenous miR-145 sponge.There was upregulation of miR-145 after ROR silencing with a specific siRNA. |
| Pubmed ID | 29280051 |
| Year | 2017 |
| Title | Long Non-coding RNA Linc-ROR Is Upregulated in Papillary Thyroid Carcinoma. |
External Links
| Links for LINC-ROR | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |