Basic Information
| LncRNA/CircRNA Name | LINC-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 |
| Ensemble | ENSG00000258609 |
| Refseq | NR_048536 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase report assay etc. |
| Sample | HCC tissues, cell lines (HH, HCCLM3, MHCC97-H, HepG2 and SMMC-7721) |
| Expression Pattern | up-regulated |
| Function Description | linc-ROR was upregulated in HCC tissues and high linc-ROR expression level predicted poor prognosis.ROR was upregulated in HCC tissues and high linc-ROR expression level predicted poor prognosis. ROR and ZEB2 interact with miR-145 by functioning as competing endogenous RNAs (ceRNAs).The disease-free survival (DFS) and over survival (OS) curves were plotted using the Kaplan-Meier method. |
| Pubmed ID | 28680141 |
| Year | 2017 |
| Title | The lincRNA-ROR/miR-145 axis promotes invasion and metastasis in hepatocellular carcinoma via induction of epithelial-mesenchymal transition by targeting ZEB2. |
External Links
| Links for LINC-ROR | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |