Basic Information
| LncRNA/CircRNA Name | LINC-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 |
| Ensemble | ENSG00000258609 |
| Refseq | NR_048536 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, MTT assay etc. |
| Sample | CRC tissues, cell lines (M5, DLD1, HCT116, SW480, SW620, and HT29) |
| Expression Pattern | up-regulated |
| Function Description | The expression level of lncRNA-ROR was elevated in CRC tissues when compared to adjacent tissues. lncRNA-ROR knockdown significantly suppressed cell proliferation and viability. Decreased lncRNA-ROR expression enhanced cell apoptosis and triggered cell cycle arrest in G0/G1 phase, while elevated lncRNA-ROR expression presented the opposite effect. Protein levels of p53 and p53 target genes were affected by lncRNA-ROR in vitro, and downregulation of lncRNA-ROR impeded tumorigenesis in vivo. |
| Pubmed ID | 28216611 |
| Year | 2017 |
| Title | Long Non-Coding RNA Reprogramming (ROR) Promotes Cell Proliferation in Colorectal Cancer via Affecting P53. |
External Links
| Links for LINC-ROR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |