Basic Information
| LncRNA/CircRNA Name | LINC-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 |
| Ensemble | ENSG00000258609 |
| Refseq | NR_048536 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy0 | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Flow cytometry assay, etc. |
| Sample | The thyroid papillary carcinoma cell line (TPC-1). |
| Expression Pattern | up-regulated |
| Function Description | We hypothesize that CSC exosomes transfer lncRNAs, importantly linc-ROR, to induce EMT and inculcate the local tumor microenvironment and the distant metastatic niche. Therapies directed towards CSCs, their exosomes and/or the lncRNAs they carry may reduce a tumor's metastatic capacity. The use of patient blood and other bodily fluids to isolate exosomes (liquid biopsy) provides a real-time, non-invasive method to monitor disease progression and determine therapy options. |
| Pubmed ID | 29967342 |
| Year | 2018 |
| Title | Thyroid cancer stem-like cell exosomes: regulation of EMT via transfer of lncRNAs. |
External Links
| Links for LINC-ROR | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |