Basic Information
| LncRNA/CircRNA Name | LINC-UFC1 |
| Synonyms | UFC1, HSPC155 |
| Region | GRCh38_1:161152776-161158856 |
| Ensemble | ENSG00000143222 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, in vitro knockdown etc. |
| Sample | HCC tissues, cell lines (BEL-7402, SK-Hep1, Huh7, MHCC-97H) |
| Expression Pattern | up-regulated |
| Function Description | Levels of the lincRNA-UFC1 were increased in HCC tissues compared with controls, and associated with tumor size, Barcelona Clinic Liver Cancer stage, and patient outcomes. Transgenic expression of the lincRNA-UFC1 in HCC cells promoted their proliferation and cell-cycle progression and inhibited apoptosis, whereas short hairpin RNA knockdown of lincRNA-UFC1 had opposite effetcs.The lincRNA-UFC1 interacted directly with the messenger RNA (mRNA) stabilizing protein HuR (encoded by ELAVL1) to increase levels of B-catenin mRNA (encoded by CTNNB1) and protein. In contrast, there was a negative correlation between levels of microRNA 34a and lincRNA-UFC1 in HCC tissues microRNA 34a reduced the stability of lincRNA-UFC1. |
| Pubmed ID | 25449213 |
| Year | 2014 |
| Title | The Long Intergenic Noncoding RNA UFC1, A Target of MicroRNA 34a, Interacts With the mRNA Stabilizing Protein HuR to Increase Levels of B-Catenin in HCC Cells. |
External Links
| Links for LINC-UFC1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |