Basic Information
| LncRNA/CircRNA Name | LINP1 |
| Synonyms | NA |
| Region | GRCh38_10:6737382-6739026 |
| Ensemble | ENSG00000223784 |
| Refseq | NR_138480 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot |
| Sample | prostate cancer tissues, cell lines (PC-3, DU-145, 22RV1, Lncap, WPMY-1) |
| Expression Pattern | up-regulated |
| Function Description | qRT-PCR results showed a higher expression of LINP1 in PCa than that of normal tissues. Compared with PCa patients with a lower expression of LINP1, those with higher expression had a higher tumor stage, lymphatic metastasis and distant metastasis rate, and lower overall survival rate. Proliferation, invasion and metastasis in cells transfected with si-LINP1 were remarkably decreased than those transfected with negative control (si-NC). |
| Pubmed ID | 30058678 |
| Year | 2018 |
| Title | Long Non-Coding RNA LINP1 Promotes the Malignant Progression of Prostate Cancer by Regulating p53. |
External Links
| Links for LINP1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |