Basic Information
| LncRNA/CircRNA Name | LINP1 |
| Synonyms | NA |
| Region | GRCh38_10:6737382-6739026 |
| Ensemble | ENSG00000223784 |
| Refseq | NR_138480 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, etc. |
| Sample | EC tissues, EC cell lines KLE, AN3CA, ECC-1 and endometrial fibroblast cell line T-HESC |
| Expression Pattern | up-regulated |
| Function Description | LINP1 was proved to be up-regulated in EC cell lines and tissues by qRT-PCR assay. CCK-8 assay and colony formation assay were conducted and the results indicated that LINP1 over-expression can promote cell proliferation in EC in vitro. The data of transwell and Matrigel assays indicated that up-regulated LINP1 can facilitate cell migration and invasion. The results of Western blotting validated that LINP1 can activate PI3K/AKT signaling. Besides, the tumor formation assay verified that LINP1 can promote tumor formation in vivo. CONCLUSIONS: Our research validated that LINP1 served as an oncogenic role in EC progression. The PI3K/AKT signaling pathway might be the underlying mechanism of EC progression. |
| Pubmed ID | 31486482 |
| Year | 2019 |
| Title | Long non-coding RNA LINP1 functions as an oncogene in endometrial cancer progression by regulating the PI3K/AKT signaling pathway |
External Links
| Links for LINP1 | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |