Basic Information
| LncRNA/CircRNA Name | ARAP1-AS1 |
| Synonyms | ARAP1 antisense RNA 1 |
| Region | GRCh38_11:72685075-72693808 |
| Ensemble | ENSG00000256007 |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR, western blot, RIP, Luciferase reporter assay |
| Sample | CC tissues,cell lines(HeLa, CaSki, SiHa, C-33A, C-4I, SW756,HaCaT),serum specimens |
| Expression Pattern | up-regulated |
| Function Description | High ARAP1-AS1 expression was closely associated with larger tumor size, advanced FIGO stage as well as lymph node metastasis. ARAP1-AS1 could directly interact with PSF to release PTB, resulting in accelerating the internal ribosome entry site (IRES)-driven translation of proto-oncogene c-Myc, thereby facilitating CC development and progression. c-Myc was able to transcriptionally activate ARAP1-AS1 by directly binding to the E-box motif located on ARAP1-AS1 promoter. |
| Pubmed ID | 31953923 |
| Year | 2020 |
| Title | Long Non-Coding RNA ARAP1-AS1 Promotes Tumorigenesis and Metastasis Through Facilitating Proto-Oncogene c-Myc Translation via Dissociating PSF/PTB Dimer in Cervical Cancer |
External Links
| Links for ARAP1-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |