Basic Information
| LncRNA/CircRNA Name | LL22NC03-N64E9.1 |
| Synonyms | NA |
| Region | GRCh38_22:15796959-15798346 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, in vitro knockdown |
| Sample | lung cancer tissues, cell lines (H1703 and H292) |
| Expression Pattern | up-regulated |
| Function Description | The level of LL22NC03-N64E9.1 in patients with lung cancer was significantly increased compared with adjacent normal lung tissues (P<0.001). The level of LL22NC03-N64E9.1 in patients with lung cancer was significantly correlated with tumor size and TNM stage (P<0.05), but not with age, sex and the presence of lymph node metastasis (P>0.05). In the H292 cells, following knockdown of LL22NC03-N64E9.1, cell proliferation and cloning were reduced. CONCLUSIONS Expression of lncRNA, LL22NC03-N64E9.1, promoted proliferation of lung cancer cells in vitro, was highly expressed in lung cancer tissues and was associated with increased overall survival (OS), tumor size, and tumor stage in patients with lung cancer. |
| Pubmed ID | 29935018 |
| Year | 2018 |
| Title | A Novel Long Noncoding RNA (lncRNA), LL22NC03-N64E9.1, Promotes the Proliferation of Lung Cancer Cells and Is a Potential Prognostic Molecular Biomarker for Lung Cancer |
External Links
| Links for LL22NC03-N64E9.1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |