Basic Information
| LncRNA/CircRNA Name | ARAP1-AS1 |
| Synonyms | NA |
| Region | GRCh38_11:72685075-72693808 |
| Ensemble | ENSG00000256007 |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | CRC tissues and adjacent nontumor tissues,The normal human colon epithelial cell line(HCoEpiC), human CRC cell lines (SW620, SW480, HT29,LoVo, and HCT116) |
| Expression Pattern | up-regulated |
| Function Description | ARAP1-AS1 was highly expressed in CRC tissues and cell lines. ARAP1-AS1 knockdown suppressed cell migration, invasion, and epithelial-mesenchymal transition (EMT).YY1 transcription factor (YY1) enhanced the transcription activity of ARAP1-AS1. The YY1/ARAP1-AS1 axis promoted CRC cell migration and invasion. YY1/ARAP1-AS1 could regulate the Wnt/?-catenin signaling pathway. |
| Pubmed ID | 31173500 |
| Year | 2019 |
| Title | YY1-Induced Upregulation of Long Noncoding RNA ARAP1-AS1 Promotes Cell Migration and Invasion in Colorectal Cancer Through the Wnt/?-Catenin Signaling Pathway |
External Links
| Links for ARAP1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |