Basic Information
| LncRNA/CircRNA Name | lnc00152 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | colorectal cancer tissues, cell lines (LoVo, SW480 and SW620) |
| Expression Pattern | up-regulated |
| Function Description | We identified that lnc00152 was aberrantly overexpressed in colorectal tumors and cancer cells and that lnc00152 was modulated by miRNA-206. lnc00152 overexpression enhanced the proliferative and invasive ability of CRC cells in vitro, promoted tumor growth in vivo, and was associated with the shorter overall survival of patients with CRC. In terms of lymph-node metastasis, the lnc00152 expression level was higher in the N1-2 grade tumors than in the N0 grade tumors. In addition, lnc00152 overexpression promoted epithelial-mesenchymal transition (EMT) and increased neuropilin-1 (NRP1) expression in the CRC cells. By contrast, lnc00152 silencing exerted a counteractive effect. |
| Pubmed ID | 29956750 |
| Year | 2018 |
| Title | Long Non-coding RNA 00152 Functions as a Competing Endogenous RNA to Regulate NRP1 Expression by Sponging With miRNA-206 in Colorectal Cancer |
External Links
| Links for lnc00152 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |