Basic Information
| LncRNA/CircRNA Name | ADAMTS9-AS2 |
| Synonyms | lncADAMTS9-AS2 |
| Region | GRCh38_3:64684909-65011468 |
| Ensemble | ENSG00000241684 |
| Refseq | NR_038264 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | Microarray, qPCR, Western blot etc |
| Sample | lung cancer tissues, cell lines (A549, SPC-A1, H23 and NCI-H520) |
| Expression Pattern | down-regulated |
| Function Description | lncADAMTS9-AS2 was lowly expressed in lung cancer tissues.High expression of ADAMTS9-AS2 in lung cancer cells significantly reduced proliferation ability and inhibited migration, as well as elevating their apoptosis rate.In vivo assay found that ADAMTS9-AS2 suppressed the lung tumor growth. Bioinformatics predicted that miR-223-3p bound directly to the ADAMTS9-AS2 and TGFBR3, which was later confirmed by luciferase reporter system.ADAMTS9-AS2 transfection increased TGFBR3 mRNA and protein expressions in lung cancer cells, but miR-223-3p transfection significantly decreased them. Besides,miR-223-3p induced cellular apoptosis while TGFBR3 group showed the complete opposite effect. It was proved that ADAMTS9-AS2 and TGFBR3 were the direct genes of miR-223-3p. MiR-223-3p promotes proliferation, migration and invasion of lung cancer cells by targeting TGFBR3. |
| Pubmed ID | 29707897 |
| Year | 2018 |
| Title | Upregulated lncRNA ADAMTS9-AS2 suppresses progression of lung cancer through inhibition of miR-223-3p and promotion of TGFBR3. |
External Links
| Links for ADAMTS9-AS2 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |