Basic Information
| LncRNA/CircRNA Name | lncARSR |
| Synonyms | LncRNA Activated in RCC with Sunitinib Resistance |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR, Western blotting analysis, Dual luciferase reporter assay |
| Sample | Bca tissue,The RT4 and 5637 cells,The SW780, J82, TCCSUP, UMUC-3 and T24 cells |
| Expression Pattern | up-regulated |
| Function Description | lncARSR was significantly up-regulated in bladder cancer. In addition, increased expression of lncARSR was positively correlated with higher histological grade and larger tumor size. Further experiments demonstrated that suppression of lncARSR attenuated the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process of Bca cells. Mechanistically, lncARSR was mainly located in the cytoplasm and acted as a miRNA sponge to positively modulate the expression of Sex-determining region Y-related high-mobility-group box transcription factor 4 (SOX4) via sponging miR-129-5p and subsequently promoted the proliferation and metastasis of Bca cells, thus playing an oncogenic role in Bca pathogenesis. |
| Pubmed ID | 31892841 |
| Year | 2020 |
| Title | LncARSR Sponges miR-129-5p to Promote Proliferation and Metastasis of Bladder Cancer Cells Through Increasing SOX4 Expression |
External Links
| Links for lncARSR | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |