Basic Information
| LncRNA/CircRNA Name | lncARSR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Luciferase reporter assays, Western blot, RIP |
| Sample | epithelial ovarian cancer tissues, cell lines (SKOV3, HO8910, ES-2, CAOV3) |
| Expression Pattern | up-regulated |
| Function Description | lncARSR expression was significantly increased in EOC tissues and correlated with FIGO stage, histological grade, lymph nodes metastasis and worse survival. Loss- and gain-of-function assays demonstrated that lncARSR promoted EOC cell proliferation and invasion. lncARSR increased ZEB1 and ZEB2 expression by competitively binding the miR-200 family to induce EMT and invasion. |
| Pubmed ID | 30034936 |
| Year | 2018 |
| Title | Long Noncoding RNA lncARSR Promotes Epithelial Ovarian Cancer Cell Proliferation and Invasion by Association With HuR and miR-200 Family. |
External Links
| Links for lncARSR | GenBank HGNC NONCODE |
| Links for epithelial ovarian cancer | OMIM COSMIC |