Basic Information
| LncRNA/CircRNA Name | lnc-BMP1-1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Doxorubicin hydrochloride (DOX) | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blotting |
| Sample | cancer tissues,lung cancer cell lines (A549, GCL82, and PC9) and a normal bronchial epithelial cell line (16HBE) |
| Expression Pattern | down-regulated |
| Function Description | When comparing lung cancer tissues with their adjacent normal tissues, the expression of lnc-BMP1-1 were decreased, especially in patients with cigarette smoking history (P=0.027), and positively associated with the expression of Cav-1 (P<0.001). When comparing to A549 cells transfected with empty vector (A549-NC cells), the expression level of Cav-1 in A549 cells with over-expressed lnc-BMP1-1 (A549-BMP cells) was increased along with the decreased level of HDAC2 protein. |
| Pubmed ID | 31901898 |
| Year | 2020 |
| Title | Down Expression of lnc-BMP1-1 Decreases That of Caveolin-1 Is Associated With the Lung Cancer Susceptibility and Cigarette Smoking History |
External Links
| Links for lnc-BMP1-1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |