Basic Information
| LncRNA/CircRNA Name | HOST2 |
| Synonyms | CERNA2, HOST2, lncRNA-HOST2 |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_134505 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Flow cytometry assay, CCK-8 assay etc. |
| Sample | HCC tissues, cell lines (HepG2, SMMC-7721 and Huh7) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA-HOST2 expression in the HCC tissues increased 2-10 times than that in the adjacent normal tissues. Compared with the HL-7702 cell line, LncRNA-HOST2 expression in HepG2, SMMC-7721 and Huh7 cell lines was all up-regulated, but the SMMC-7721 cell had the highest Lnc-HOST2 expression. In comparison with the control and NC groups, cloned cells reduced, cell apoptosis increased, clone-forming ability weakened and inhibitory rate of colony formation increased in the experimental group. |
| Pubmed ID | 28143959 |
| Year | 2017 |
| Title | Effects of LncRNA-HOST2 on cell proliferation, migration, invasion and apoptosis of human hepatocellular carcinoma cell line SMMC-7721. |
External Links
| Links for HOST2 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |