Basic Information
| LncRNA/CircRNA Name | lnc-IL7R |
| Synonyms | NA |
| Region | GRCh38_5:35852695-35879603 |
| Ensemble | ENSG00000168685 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical intraepithelial neoplasia |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RNAi etc. |
| Sample | cervical intraepithelial neoplasia tissues, cell lines (Hela and SiHa) |
| Expression Pattern | up-regulated |
| Function Description | We here investigated the clinical role of inflammation-related LncRNA-IL7R (Lnc-IL7R) in healthy cervical tissue (n=15), CIN 1/2/3 (n=35), cervical cancer (n=70), and clarified its function via knockdown in vitro and in vivo. The results showed that the expression of Lnc-IL7R was increased from normal tissues to neoplastic lesions and cervical cancer. Patients with high expression of Lnc-IL7R had poor prognosis with short overall survival time, and cox regression analysis revealed that Lnc-IL7R could be independent prognostic factor for cervical cancer. These data indicated that Lnc-IL7R predicts a poor clinical outcome of cervical cancer patients, and knockdown of Lnc-IL7R is amenable to the treatment of cervical cancer. |
| Pubmed ID | 29720427 |
| Year | 2018 |
| Title | Up-regulation of inflammation-related LncRNA-IL7R predicts poor clinical outcome of patients with cervical cancer. |
External Links
| Links for lnc-IL7R | GenBank HGNC NONCODE |
| Links for cervical intraepithelial neoplasia | OMIM COSMIC |