Basic Information
| LncRNA/CircRNA Name | lnc-NA |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrioid endometrial cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | EEC and adjacent normal endometrial tissues ,cell lines(KLE, RL95-2, Ishikawa, HEC-1-b and ESC) |
| Expression Pattern | down-regulated |
| Function Description | Lnc-NA expression was down-regulated in 30 EEC cases and in EEC cell lines compared with that in the paired adjacent tissues and normal endometrial cells.Overexpressing Lnc-NA decreased EEC cell proliferation, migration and invasion and promoted apoptosis via inactivation of the apoptosis signalling pathway.Lnc-NA expression was positively correlated with NR4A1. Furthermore, Lnc-NA regulated NR4A1 expression and activated the apoptosis signalling pathway to inhibit tumour progression. |
| Pubmed ID | 31050196 |
| Year | 2019 |
| Title | Lnc-NA Inhibits Proliferation and Metastasis in Endometrioid Endometrial Carcinoma Through Regulation of NR4A1 |
External Links
| Links for lnc-NA | GenBank HGNC NONCODE |
| Links for endometrioid endometrial cancer | OMIM COSMIC |