Basic Information
| LncRNA/CircRNA Name | ASAP1-IT1 |
| Synonyms | ASAP1-IT1, ASAP1-IT, ASAP1IT, ASAP1IT1, DDEF1IT1, HSPC054, NCRNA00050 |
| Region | NA |
| Ensemble | NA |
| Refseq | NR_002765 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | Western blot |
| Sample | lung cancer tissues, cell lines (A549, H1299, H460, SPCA-1 and SK-MES-1,HBE) |
| Expression Pattern | up-regulated |
| Function Description | interference on ASAP1-IT1 expression could inhibit the proliferation of NSCLC cells.the interference on ASAP1-IT1 expression could block the migration and invasion ability of NSCLC cells. ASAP1-IT1 could regulate the biological behaviors of NSCLC cells through phosphatase and tensin homolog deleted on chromosome ten (PTEN)/serine-threonine kinase (AKT) pathway. |
| Pubmed ID | 29364481 |
| Year | 2018 |
| Title | Long non-coding RNA ASAP1-IT1 promotes cell proliferation, invasion and metastasis through the PTEN/AKT signaling axis in non-small cell lung cancer. |
External Links
| Links for ASAP1-IT1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |