Basic Information
| LncRNA/CircRNA Name | lnc-p23154 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | oral squamous cell carcinoma tissues, cell lineS(SCC-15, SCC-25, CAL-27, UM1) |
| Expression Pattern | up-regulated |
| Function Description | we identified a novel lncRNA lnc-p23154 which is associated with OSCC patient metastasis and the promotion of OSCC cell migration and invasion in vitro and in vivo. In addition, lnc-p23154 is mainly located in the nucleus and binds to the promoter region of miR-378a-3p. Lnc-p23154 is upregulated in OSCC. Additionally, ectopic expression of lnc-p23154 increased the expression of MMP1, CTGF, and EMT-related genes. |
| Pubmed ID | 30026052 |
| Year | 2018 |
| Title | LncRNA-p23154 Promotes the Invasion-Metastasis Potential of Oral Squamous Cell Carcinoma by Regulating Glut1-mediated Glycolysis. |
External Links
| Links for lnc-p23154 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |