Basic Information
| LncRNA/CircRNA Name | lncRNA-AK058803 |
| Synonyms | NA |
| Region | GRCh38_10:86948677-86949657 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, RNA pull-down assay, Cell proliferation assay etc. |
| Sample | HCC tissues, cell lines (HepG2, SK-Hep1, HEK 293T) |
| Expression Pattern | down-regulated |
| Function Description | We found that lncRNA-AK058003 is down-regulated in hepatocellular carcinoma tissues and it is associated with the relapse and metastasis of the cancer. Furthermore, lncRNA-AK058003 acts as a tumor suppressor, suppressing hepatocellular carcinoma cell proliferation and metastasis in vitro and in vivo. lncRNA-AK058003 can reduce mRNA stabilizing protein HuR, which results in the inhibition of the expression of ?-synuclein. |
| Pubmed ID | 28035067 |
| Year | 2017 |
| Title | Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of ?-synuclein in hepatocellular carcinoma cells. |
External Links
| Links for lncRNA-AK058803 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |