Basic Information
| LncRNA/CircRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | bladder cancer cell line T24 |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-ATB was a molecular sponge of miR-126,and exerted tumor promoting effects by down-regulation of miR-126. Moreover, KRAS was a direct target of miR-126, and negatively regulated by miR-126. Finally, overexpression of KRAS increased cell viability, migration and invasion, as well as activated PI3K/AKT and mTOR signal pathways in T24 cells. |
| Pubmed ID | 29321082 |
| Year | 2018 |
| Title | Long noncoding RNA ATB promotes proliferation, migration and invasion in bladder cancer by suppressing microRNA-126. |
External Links
| Links for lncRNA-ATB | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |