Basic Information
| LncRNA/CircRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay, MTT assay etc. |
| Sample | cell line (SKBR-3) |
| Expression Pattern | up-regulated |
| Function Description | We identified long noncoding RNA activated by TGF-B (lnc-ATB) was the most remarkably upregulated lncRNA in TR SKBR-3 cells and the tissues of TR breast cancer patients. We found that lnc-ATB could promote trastuzumab resistance and invasion-metastasis cascade in breast cancer by competitively biding miR-200c, up-regulating ZEB1 and ZNF-217, and then inducing EMT. In addition, we also found that the high level of lnc-ATB was correlated with trastuzumab resistance of breast cancer patients. |
| Pubmed ID | 25871474 |
| Year | 2015 |
| Title | LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer. |
External Links
| Links for lncRNA-ATB | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |