Basic Information
| LncRNA/CircRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR etc. |
| Sample | gastric cancer tissues, cell lines (MKN1, MKN7, MKN28, MKN45, MKN74 etc.) |
| Expression Pattern | differential expression |
| Function Description | The high lncRNA-ATB group experienced a lower overall survival rate compared with the low lncRNA-ATB group, and multivariate analysis indicated that lncRNA-ATB was an independent prognostic factor.LncRNA-ATB plays an important role in EMT to promote invasion and metastasis through the TGFb/miR-200s/ZEB axis, resulting in a poor prognosis in GC. LncRNA-ATB is a novel biomarker of lncRNA, indicative of a poor prognosis in GC patients. |
| Pubmed ID | 25986864 |
| Year | 2015 |
| Title | A Long Non-coding RNA Activated by Transforming Growth Factor-B is an Independent Prognostic Marker of Gastric Cancer. |
External Links
| Links for lncRNA-ATB | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |