Basic Information
| LncRNA/CircRNA Name | lncRNA-cCSC1 |
| Synonyms | gene symbol MAPKAPK5-AS1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blot assay |
| Sample | CRC and adjacent normal tissues,colon mucosal epithelial cell line NCM460 and human CRC cell lines Caco2, SW480, SW620, LoVo, HT29, and HCT116 |
| Expression Pattern | up-regulated |
| Function Description | The biological functions of lncRNA-cCSC1 were assessed in vitro and vivo through the silencing or upregulation of its expression. The depletion of lncRNA-cCSC1 markedly inhibited the self-renewal capacity of the CRCSCs and reduced their drug resistance to 5-fluorouracil. In contrast, lncRNA-cCSC1 overexpression increased the self-renewal effect. Furthermore, aberrant lncRNA-cCSC1 expression resulted in a concomitant alteration of smoothened (SMO) and GLI family zinc finger 1 (Gli1) expression in the Hedgehog (Hh) signaling pathway. |
| Pubmed ID | 31680315 |
| Year | 2020 |
| Title | LncRNA-cCSC1 Modulates Cancer Stem Cell Properties in Colorectal Cancer via Activation of the Hedgehog Signaling Pathway |
External Links
| Links for lncRNA-cCSC1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |