Basic Information
| LncRNA/CircRNA Name | lncRNA-CF129 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | The PANC-1 and BxPC-3 cell lines, pancreatic cancer and corresponding non-tumor tissue |
| Expression Pattern | down-regulated |
| Function Description | CF129 levels were markedly lower in PC compared with paired non-tumor adjacent tissues. Low CF129 expression predicted short overall survival in PC patients. CF129 inhibited invasion and metastasis of PC cells in a FOXC2-dependent manner. In addition, CF129 regulates FOXC2 transcription through association with mutant p53. CF129 directly binds to p53 and E3 ligase MKRN1, and such an interaction leading to p53 protein ubiquitination and degradation. Furthermore, CF129 is a hypoxia-responsive lncRNA, which is transcriptionally downregulated by binding between HIF-1?/HDAC1 complex and CF129 promoter. Finally, it is revealed that HIF-1? is reciprocally regulated by FOXC2 in transcriptional level. Clinically, CF129 downregulation coordinates overexpression of FOXC2. |
| Pubmed ID | 31367258 |
| Year | 2019 |
| Title | Hypoxia-induced feedback of HIF-1? and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein |
External Links
| Links for lncRNA-CF129 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |