Basic Information
| LncRNA/CircRNA Name | lncRNA-CIR |
| Synonyms | cartilage injury-related |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blot analysis |
| Sample | Tumor and adjacent normal tissue samples,osteosarcoma cell lines MG63 and 143B, and human osteoblasts hFOB1.19,osteosarcoma cell lines U2OS and SAOS2 |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-CIR was up-regulated in osteosarcoma tissues and cells, which was respectively relative to adjacent normal tissues and normal osteoblasts. The expression of lncRNA-CIR was evidently correlated with disease stages, distant metastasis and differentiation of osteosarcoma patients, and the high expression of lncRNA-CIR indicated a poor prognosis. Furthermore, the reduction of lncRNA-CIR could restrict proliferation, invasion and migration, but promote apoptosis of osteosarcoma cells in vitro. Meanwhile, inhibited lncRNA-CIR also restrained tumor growth and osteosarcoma cell proliferation, whereas accelerated apoptosis of osteosarcoma cells in vivo. |
| Pubmed ID | 31889901 |
| Year | 2019 |
| Title | Degradation of Long Non-Coding RNA-CIR Decelerates Proliferation, Invasion and Migration, but Promotes Apoptosis of Osteosarcoma Cells |
External Links
| Links for lncRNA-CIR | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |