Basic Information
| LncRNA/CircRNA Name | lncRNA-Glu |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Western blot, Microarray |
| Sample | TNBC tissues,cell lines |
| Expression Pattern | down-regulated |
| Function Description | LncRNA-Glu can inhibit glutamate transport activity and transcriptional activity of its target gene VGLUT2 via specific binding. GPER-mediated reduction of lncRNA-Glu promotes glutamate transport activity and transcriptional activity of VGLUT2. |
| Pubmed ID | 32030797 |
| Year | 2020 |
| Title | GPER-regulated lncRNA-Glu promotes glutamate secretion to enhance cellular invasion and metastasis in triple-negative breast cancer |
External Links
| Links for lncRNA-Glu | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |