Basic Information
| LncRNA/CircRNA Name | lncRNA-HIT |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RNAi |
| Sample | cell lines (A549 and SK-MES-1) |
| Expression Pattern | differential expression |
| Function Description | In the present study, we investigated the effects of lncRNA-HIT (HOXA transcript induced by TGFB) expression on non-small cell lung cancer (NSCLC) cell phenotype with the gain-of-function and loss-of-function assays. We found that ectopic expression or knockdown of lncRNA-HIT markedly increased or decreased NSCLC cell proliferation, respectively. |
| Pubmed ID | 28429752 |
| Year | 2017 |
| Title | lncRNA-HIT promotes cell proliferation of non-small cell lung cancer by association with E2F1 |
External Links
| Links for lncRNA-HIT | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |