Basic Information
| LncRNA/CircRNA Name | lncRNA-HIT |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | breast cancer tissues, cell lines (NMuMG, 4T1) |
| Expression Pattern | up-regulated |
| Function Description | The level of expression of lncRNA-HIT in normal breast tissue was low and gradually increased to invasive carcinoma suggesting lncRNA-HIT may play a role in tumor progression in humans. These data further support the findings demonstrating the involvement of lncRNA-HIT in EMT and invasion as observed in NMuMG and 4T1 cells, and suggest that conserved human lncRNA-HIT could play a pivotal role in breast cancer metastasis. |
| Pubmed ID | 25605728 |
| Year | 2015 |
| Title | Long non-coding RNAs regulated by TGFB1 lncRNA-HIT mediated TGFB1-induced epithelial to mesenchymal transition in mammary epithelia. |
External Links
| Links for lncRNA-HIT | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |