Basic Information
| LncRNA/CircRNA Name | lncRNA-JADE |
| Synonyms | JADRR, LINC00915, lncRNA-JADE |
| Region | GRCh38_4:128768228-128769948 |
| Ensemble | ENSG00000280711 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, RNAi, Western blot, RIP, in vitro knockdown etc. |
| Sample | breast cancer tissues, cell lines (293T, NIH3T3, MCF7, 4T1-luciferase etc.) |
| Expression Pattern | up-regulated |
| Function Description | Markedly higher levels of lncRNA-JADE were observed in human breast tumours in comparison with normal breast tissues. Knockdown of lncRNA-JADE significantly inhibited breast tumour growth in vivo. |
| Pubmed ID | 24097061 |
| Year | 2013 |
| Title | A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. |
External Links
| Links for lncRNA-JADE | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |