Basic Information
| LncRNA/CircRNA Name | lncRNA-LALR1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RIP etc. |
| Sample | liver cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-LALR1 promotes cell cycle progression and accelerates hepatocyte proliferation during liver regeneration by activating Wnt/B-Catenin signaling. Our results indicate that lncRNA-LALR1 promotes cell cycle progression and accelerates hepatocyte proliferation during liver regeneration by activating Wnt/B-Catenin signaling. Thus, we propose that pharmacological intervention targeting lncRNA-LALR1 may be therapeutically beneficial in liver failure and liver transplantation by inducing liver regeneration. |
| Pubmed ID | 23483581 |
| Year | 2013 |
| Title | Long noncoding RNAs associated with liver regeneration 1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/B-Catenin signaling. |
External Links
| Links for lncRNA-LALR1 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |