Basic Information
| LncRNA/CircRNA Name | lncRNA-LET |
| Synonyms | NPTN-IT1, lncRNA-LET |
| Region | GRCh38_15:73567012-73569294 |
| Ensemble | ENSG00000281183 |
| Refseq | NR_103844 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | ccRCC and matched adjacent non-tumor tissues,cell lines (Caki-1, 786-O, 769-P,293T ) |
| Expression Pattern | down-regulated |
| Function Description | LncRNA-LET expression was lower in ccRCC tissues than that in the matched adjacent non-tumor tissues (n = 16). In vitro, lncRNA-LET overexpression induced cell cycle arrest, promoted apoptosis and impaired mitochondrial membrane potential, whereas its knockdown exerted opposite effects. Moreover, we noted that lncRNA-LET may act as a target for oncomiR miR-373-3p. |
| Pubmed ID | 31768131 |
| Year | 2019 |
| Title | LncRNA-LET Inhibits Cell Growth of Clear Cell Renal Cell Carcinoma by Regulating miR-373-3p |
External Links
| Links for lncRNA-LET | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |