Basic Information
| LncRNA/CircRNA Name | lncRNA-LET |
| Synonyms | NPTN-IT1, lncRNA-LET |
| Region | GRCh38_15:73567012-73569294 |
| Ensemble | ENSG00000281183 |
| Refseq | NR_103844 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR etc. |
| Sample | renal tumour tissues |
| Expression Pattern | down-regulated |
| Function Description | After marker discovery, we used the training set to detect the levels of these promising lncRNAs by RT and quantitative polymerase chain reaction (RT-qPCR) in a cohort of 24 patients with ccRCC and 27 normal controls. Five lncRNAs (lncRNA-LET, PVT1, PANDAR, PTENP1 and linc00963) were significantly downregulated in the serum of patients compared to the healthy controls. |
| Pubmed ID | 26878386 |
| Year | 2016 |
| Title | A serum-circulating long noncoding RNA signature can discriminate between patients with clear cell renal cell carcinoma and healthy controls. |
External Links
| Links for lncRNA-LET | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |