Basic Information
| LncRNA/CircRNA Name | lncRNA-PRAL |
| Synonyms | PRAL, lncRNA-PRAL |
| Region | GRCh38_17:6772831-6776116 |
| Ensemble | ENSG00000279296 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot etc. |
| Sample | lung cancer tissues, cell lines (H-125, A549, 95D, NCI-H929, and H1975) |
| Expression Pattern | down-regulated |
| Function Description | The transcript level of PRAL in human lung cancer was remarkably decreased in vivo compared with their adjacent non-cancerous counterparts, and the protein levels of P53 were accordingly suppressed. Moreover, the expression of PRAL was also decreased in all of the 5 lung cancer cell lines. |
| Pubmed ID | 28396580 |
| Year | 2017 |
| Title | P53 Regulation-Association Long Non-Coding RNA (LncRNA PRAL) Inhibits Cell Proliferation by Regulation of P53 in Human Lung Cancer |
External Links
| Links for lncRNA-PRAL | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |