Basic Information
| LncRNA/CircRNA Name | lncRNA-SRA1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR etc. |
| Sample | osteosarcoma tissues and their matched healthy tissues ,SJSA-1 and U2OS (human OS line) cells |
| Expression Pattern | down-regulated |
| Function Description | LncRNA-SRA1 expression was downregulated in osteosarcoma tissues and cells compared with that in corresponding normal tissues, whereas microRNA-208a expression was upregulated in osteosarcoma tissues.LncRNA-SRA1 inhibited cell proliferation, and upregulation of LncRNA-SRA1 restrained cell migration and invasion but boosted the apoptosis rate in osteosarcoma cells.In addition, LncRNA-SRA1 targeting microRNA-208a was involved in the progression of osteosarcoma. |
| Pubmed ID | 31106680 |
| Year | 2019 |
| Title | LncRNA-SRA1 Suppresses Osteosarcoma Cell Proliferation While Promoting Cell Apoptosis |
External Links
| Links for lncRNA-SRA1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |