Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bile duct carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | BDC tissues and their matched adjacent normal tissues ,human BDC cell lines(LIPF155C, CCLP1, QBC939, huh28) ,normal intrahepatic bile duct epithelial cell line HIBEC |
| Expression Pattern | up-regulated |
| Function Description | lncRNA UCA1 and CLIC1 were both significantly upregulated in BDC, while the expression of miR-122 declined compared with the normal group.The target relationship among UCA1, CLIC1 and miR-122 was verified.UCA1 promoted BDC cell migration and invasiveness, while miR-122 inhibited their progression.The ERK/MAPK signaling pathway was activated after upregulating UCA1.LncRNA-UCA1 promoted the metastasis of BDC cells by regulating the expression of miR-122 and its downstream gene mRNA CLIC1 and promoted the activation of the ERK/MAPK pathway, which expanded the horizons of targeted therapy of cholangiocarcinoma. |
| Pubmed ID | 31106658 |
| Year | 2019 |
| Title | Upregulated lncRNA-UCA1 Contributes to Metastasis of Bile Duct Carcinoma Through Regulation of miR-122/?CLIC1?and Activation of the ERK/MAPK Signaling Pathway |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for bile duct carcinoma | OMIM COSMIC |