Basic Information
| LncRNA/CircRNA Name | RUNX2-AS1 |
| Synonyms | NA |
| Region | GRCh38_6:45573346-45576770 |
| Ensemble | ENSG00000261080 |
| Refseq | XR_001744135 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | multiple myeloma |
| ICD-0-3 | C42.1 |
| Methods | qPCR, etc. |
| Sample | 15 patients with newly diagnosed MM and 12 normal subjects |
| Expression Pattern | down-regulated |
| Function Description | In summary, our results indicated a key role of exosomal lncRUNX2-AS1 in transferring from MM cells to MSCs in osteogenic differentiation, through a unique exosomal lncRUNX2-AS1/RUNX2 pathway. |
| Pubmed ID | 29895968 |
| Year | 2018 |
| Title | Exosome-mediated transfer of lncRUNX2-AS1 from multiple myeloma cells to MSCs contributes to osteogenesis. |
External Links
| Links for RUNX2-AS1 | GenBank HGNC NONCODE |
| Links for multiple myeloma | OMIM COSMIC |