Basic Information
| LncRNA/CircRNA Name | lncSOX4 |
| Synonyms | NA |
| Region | GRCh38_6:21592768-21598619 |
| Ensemble | ENSG00000124766 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Northern blot |
| Sample | osteosarcoma tissue, cell lines (293T, Mg63, U-20S) |
| Expression Pattern | up-regulated |
| Function Description | LncSox4 silencing attenuated but lncSox4 overexpression promoted cell viability (all P < 0.001) and migration (P < 0.01) in the Mg63 cells.we found lncSox4 regulation of osteosarcoma is involved in B-catenin, and overexpression of lncSox4 could stable B-catenin expression. |
| Pubmed ID | 29441981 |
| Year | 2017 |
| Title | Long non-coding RNA Sox4 promotes proliferation and migration by activating Wnt/B-catenin signaling pathway in osteosarcoma. |
External Links
| Links for lncSOX4 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |