Basic Information
| LncRNA/CircRNA Name | lnc-TALC |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | temozolomide | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | GBM tissues ,human GBM cells (LN229 and U251) ,TMZ-resistant GBM cells (229R, 251R, 551WR, and HG7R) |
| Expression Pattern | down-regulated |
| Function Description | lnc-TALC correlated with TMZ resistance via competitively binding miR-20b-3p to facilitate c-Met expression.A phosphorylated AKT/FOXO3 axis regulated lnc-TALC expression in TMZ-resistant GBM cells.Furthermore, lnc-TALC increased MGMT expression by mediating the acetylation of H3K9, H3K27 and H3K36 in MGMT promoter regions through the c-Met/Stat3/p300 axis.lnc-TALC is required for TMZ resistance and GBM recurrence.Transfection of constitutively active FOXO3 significantly downregulated lnc-TALC levels in TMZ-resistant cells, whereas DNA-binding domain-truncated mutants (FOXO3-Mut) had no effect on lnc-TALC levels. |
| Pubmed ID | 31053733 |
| Year | 2019 |
| Title | Lnc-TALC Promotes O?6-methylguanine-DNA Methyltransferase Expression via Regulating the c-Met Pathway by Competitively Binding With miR-20b-3p |
External Links
| Links for lnc-TALC | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |