Basic Information
| LncRNA/CircRNA Name | lncTCF7 |
| Synonyms | WSPAR, LncTCF7, TCONS_00009511, NR_033449 |
| Region | GRCh38_5:133913677-133917269 |
| Ensemble | ENSG00000081059 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, Northern blot, FISH etc. |
| Sample | cell lines (Hep3B, Huh7, and PLC) |
| Expression Pattern | up-regulated |
| Function Description | Here, using transcriptome microarray analysis, we identified a long noncoding RNA (lncRNA) termed lncTCF7 that is highly expressed in HCC tumors and liver CSCs. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Our data suggest that lncTCF7-mediated Wnt signaling primes liver CSC self-renewal and tumor propagation. |
| Pubmed ID | 25842979 |
| Year | 2015 |
| Title | The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling. |
External Links
| Links for lncTCF7 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |