Basic Information
| LncRNA/CircRNA Name | lncTCF7 |
| Synonyms | WSPAR, LncTCF7, TCONS_00009511, NR_033449 |
| Region | GRCh38_5:134114711-134151865 |
| Ensemble | ENSG00000081059 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, ChIP, Dual luciferase reporter assay etc. |
| Sample | cell lines (A549 and 95D) |
| Expression Pattern | up-regulated |
| Function Description | We showed that lncTCF7 increased slug expression to promote the invasive capability of NSCLC cells and upregulated EpCAM expression to promote the self-renewal. |
| Pubmed ID | 27766570 |
| Year | 2017 |
| Title | Long noncoding RNA TCF7 promotes invasiveness and self-renewal of human non-small cell lung cancer cells. |
External Links
| Links for lncTCF7 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |