Basic Information
| LncRNA/CircRNA Name | lncTCF7 |
| Synonyms | WSPAR, LncTCF7, TCONS_00009511, NR_033449 |
| Region | GRCh38_5:134114711-134151865 |
| Ensemble | ENSG00000081059 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | HCC cell lines (SK-Hep-1, BEL-7402) |
| Expression Pattern | up-regulated |
| Function Description | We demonstrate that IL-6 could induce lncTCF7 expression in a time- and dose-dependent manner, and we showed that IL-6 transcriptionally activated the expression of lncTCF7 in HCC cells by activating STAT3, a transcription activator which binds to promoter regions of lncTCF7. Furthermore, knocking-down STAT3 and inhibiting STAT3 activation reduced lncTCF7 expression. Importantly, RNA interference-based attenuation of lncTCF7 prevented IL-6-induced EMT and cell invasion. |
| Pubmed ID | 26452542 |
| Year | 2015 |
| Title | Long noncoding RNA lncTCF7, induced by IL-6/STAT3 transactivation, promotes hepatocellular carcinoma aggressiveness through epithelial-mesenchymal transition |
External Links
| Links for lncTCF7 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |