Basic Information
| LncRNA/CircRNA Name | lncUSMycN |
| Synonyms | MYCNUT, MYCNUN, lncUSMycN |
| Region | GRCh38_2:15920399-15936017 |
| Ensemble | ENSG00000223850 |
| Refseq | NR_125783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi etc. |
| Sample | neuroblastoma tissues |
| Expression Pattern | up-regulated |
| Function Description | The lncUSMycN gene was coamplified with MYCN in 88 of 341 human neuroblastoma tissues. lncUSMycN RNA bound to the RNA-binding protein NonO, leading to N-Myc RNA upregulation and neuroblastoma cell proliferation. High levels of lncUSMycN and NonO expression in human neuroblastoma tissues independently predicted poor patient prognoses. Treatment with antisense oligonucleotides targeting lncUSMycN in neuroblastoma-bearing mice statistically significantly hindered tumor progression. |
| Pubmed ID | 24906397 |
| Year | 2014 |
| Title | Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression. |
External Links
| Links for lncUSMycN | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |