Basic Information
| LncRNA/CircRNA Name | ZNF674-1 |
| Synonyms | ZNF674, MRX92, ZNF673B |
| Region | GRCh38_X:46497727-46545457 |
| Ensemble | ENSG00000251192 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | Microarray, qPCR etc. |
| Sample | NPC tissues |
| Expression Pattern | up-regulated |
| Function Description | In primary NPC, upregulation of lnc-C22orf32-1, lnc-AL355149.1-1, and lnc-ZNF674-1 was observed. High levels of lnc-C22orf32-1 and lnc-AL355149.1-1 were significantly associated with the male patients. In addition, increased expression of lnc-C22orf32-1 and lnc-ZNF674-1 was associated with advanced tumor stages. Recurrent NPC displayed a distinctive lncRNA expression pattern. lnc-BCL2L11-3 was significantly increased in the recurrent NPC tissues. In addition, significant reduction of lnc-AL355149.1-1 and lnc-ZNF674-1 was observed in the recurrent NPC tissues. |
| Pubmed ID | 24822202 |
| Year | 2014 |
| Title | Differential expression of long noncoding RNA in primary and recurrent nasopharyngeal carcinoma. |
External Links
| Links for ZNF674-1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |