Basic Information
| LncRNA/CircRNA Name | LNMAT2 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | bladder cancer (MIBC) tissues and paired 5 normal adjacent tissues ,human BCa cell lines(UM-UC-3 (CRL-1749), 5637 (HTB-9), and T24 (HTB-4)), and immortalized normal human urothelial cell line SV-HUC-1 (CRL-9520) ,Urine and blood samples |
| Expression Pattern | up-regulated |
| Function Description | LNMAT2 overexpression correlated with BCa LN metastasis.BCa cell-secreted exosome-mediated lymphangiogenesis promoted LN metastasis in BCa in a VEGF-C-independent manner.LNMAT2 stimulated human lymphatic endothelial cell (HLEC) tube formation and migration in vitro and enhanced tumor lymphangiogenesis and LN metastasis in vivo.LNMAT2 was loaded to BCa cell-secreted exosomes by directly interacting with heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1).Subsequently, exosomal LNMAT2 was internalized by HLECs and epigenetically upregulated prospero homeobox 1 (PROX1) expression by recruitment of hnRNPA2B1 and increasing the H3K4 trimethylation level in the PROX1 promoter, ultimately resulting in lymphangiogenesis and lymphatic metastasis. |
| Pubmed ID | 31593555 |
| Year | 2019 |
| Title | Exosomal Long Noncoding RNA LNMAT2 Promotes Lymphatic Metastasis in Bladder Cancer |
External Links
| Links for LNMAT2 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |