Basic Information
| LncRNA/CircRNA Name | LOC653786 |
| Synonyms | NA |
| Region | GRCh38_16:22545698-22576865 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | RNA-seq, qPCR, Western blot, Luciferase reporter assay |
| Sample | RCC tissues, cell lines (ACHN, 786-O, Caki-2 and HK-2) |
| Expression Pattern | up-regulated |
| Function Description | LOC653786 was upregulated in RCC tissues and cell lines, and this lncRNA promoted growth and cell cycle progression of RCC cells. Moreover, we showed that LOC653786 elevated the expression of forkhead box M1 (FOXM1) and its downstream target genes cyclin D1 and cyclin B1 in RCC cells. Reporter assay revealed that LOC653786 enhanced the transcriptional activity of FOXM1 gene promoter.In conclusion, our results demonstrate that LOC653786 accelerates growth and cell cycle progression of RCC cells via upregulating FOXM1, suggesting that the 'LOC653786/FOXM1' pathway may serve as a novel target for RCC treatment. |
| Pubmed ID | 29552295 |
| Year | 2018 |
| Title | LncRNA LOC653786 promotes growth of RCC cells via upregulating FOXM1. |
External Links
| Links for LOC653786 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |