Basic Information
| LncRNA/CircRNA Name | LOC728228 |
| Synonyms | LOC728228 |
| Region | GRCh38_20:4193065-4195943 |
| Ensemble | ENSG00000230176 |
| Refseq | NR_033917 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | Microarray, qPCR, RNAi, Western blot etc. |
| Sample | cell line (16HBE) |
| Expression Pattern | up-regulated |
| Function Description | LOC728228 was upregulated relative to its expression in control untransformed16HBE (16HBE-N) cells. LOC728228 knockdown inhibited cell proliferation, caused G0/G1-phase cell-cycle arrest, reduced cellular migration, suppressed colony formation in vitro, and inhibited tumor growth in a nude mouse xenograft model. |
| Pubmed ID | 25820656 |
| Year | 2015 |
| Title | Functional role and mechanism of lncRNA LOC728228 in malignant 16HBE cells transformed by anti-benzopyrene-trans-7,8-dihydrodiol-9,10-epoxide. |
External Links
| Links for LOC728228 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |